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ey0016.5-16 | Basic Science - Bone | ESPEYB16

5.16. Discovery of a periosteal stem cell mediating intramembranous bone formation

S Debnath , AR Yallowitz , J McCormick , S Lalani , T Zhang , R Xu , N Li , Y Liu , YS Yang , M Eiseman , JH Shim , M Hameed , JH Healey , MP Bostrom , DA Landau , MB Greenblatt

Abstract: Nature. 2018 Oct;562(7725):133139.In brief: A newly discovered periosteal stem cell pool with features distinct from other skeletal mesenchymal stem cells (MSCs) is present in murine and human bone and reveals a pivotal function in intramembranous ossification, cortical bone architecture and fracture healing in conditional knockout mouse strains.</st...

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ey0020.2-10 | Long-Acting Growth Hormone (LAGH) | ESPEYB20

2.10. Long-acting PEGylated growth hormone in children with idiopathic short stature

X Luo , S Zhao , Y Yang , G Dong , L Chen , P Li , F Luo , C Gong , Z Xu , X Xu , H Gong , H Du , L Hou , Y Zhong , Q Shi , X Chen , X Chen , L Xu , R Cheng , C Su , Y Ma , L Xu , L Zhang , H Lu

Brief summary: This randomized, multicenter, controlled, phase II study compared the effects of high-dose (HD) once-weekly PEGylated-recombinant human growth hormone (PEG-rhGH) to low-dose (LD) and to an untreated control group of children with idiopathic short stature (ISS) over a period of 52 weeks. PEG-rhGH was effective in increasing height gain in a dose dependent manner with both doses being well tolerated during the observation period.PEG-rhGH is ...

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ESPE Yearbook of Paediatric Endocrinology

5.16. Discovery of a periosteal stem cell mediating intramembranous bone formation

2.10. Long-acting PEGylated growth hormone in children with idiopathic short stature

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